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Category:Windows-only softwareOne of the major factors responsible for the development of metastatic cancer is the ability of cancer cells to escape immunosurveillance. The role of natural killer (NK) cells in the control of cancer has been established by numerous in vitro and in vivo studies. We and others have demonstrated that NK cells play an important role in the control of cancer metastasis. We have also shown that NK cells exert their control of cancer by direct attack of cancer cells and by activating factors produced by immune cells (IL-2, IFNgamma, GM-CSF). We have also demonstrated that by using cytokine-induced killer (CIK) cells, the effectiveness of NK cell therapy can be enhanced. Our hypothesis is that through the use of immunologic and non-immunologic agents, the capacity of NK cells to lyse tumor cells will be significantly increased. To test this hypothesis, we propose to establish a team of academic, clinical and industrial investigators, who will work together to: (1) develop the optimal non-immunologic combination of agents to increase the efficacy of the NK cell therapy; (2) develop the optimal immunologic combination of agents to enhance the efficacy of the NK cell therapy; and (3) conduct a preclinical evaluation of the efficacy of these agents in a mouse model. Our long term goal is to provide a new option for cancer therapy. Our research group has experience in the development of immunologic and non-immunologic agents for the treatment of cancer. Using this experience and the clinical and laboratory research available in our cancer center, we have the resources to conduct the proposed project. The goal of this project is to develop a new option for the treatment of cancer, which will also enhance the efficacy of the innate immune system. to the BVDV strains, but differ among different herds in the Netherlands.
Altogether, the present study shows that the use of the VNT as the sole test for BVDV control in countries where BVDV-2 strains are prevalent is not justified. Because a large number of clinical isolates are available and the growth characteristics of these strains are very similar, the VNT is not suitable to identify BVDV strains. Testing for the presence of the IS711 E2 protein of the strains showed that the IS711 PCR is the most suitable alternative for BVDV typing in countries where BVDV-2 predominates. The ac619d1d87
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